发明授权
- 专利标题: Nonantigenic keratinous protein material
- 专利标题(中): 非抗原性角质蛋白材料
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申请号: US978768申请日: 1992-11-19
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公开(公告)号: US5358935A公开(公告)日: 1994-10-25
- 发明人: Robert A. Smith , Cheryl R. Blanchard , James Lankford, Jr.
- 申请人: Robert A. Smith , Cheryl R. Blanchard , James Lankford, Jr.
- 申请人地址: MS Jackson
- 专利权人: Smith; Robert Allen
- 当前专利权人: Smith; Robert Allen
- 当前专利权人地址: MS Jackson
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; A61L27/22 ; A61L27/26 ; A61L27/34 ; A61L27/44 ; A61L27/50 ; C07K14/47 ; A61F2/02 ; A61K37/12 ; C07K3/02
摘要:
The present invention is a new nonantigenic keratinous protein material that may be used as a number of purposes, including correction of soft tissue deficiencies and the creation of biomedical implants and implant coatings. The present invention also includes processes for using the nonantigenic keratinous protein material for soft tissue augmentation, creating implants, and the coating of biocompatible implants. The nonantigenic keratinous protein material can be formed by obtaining nonantigenic keratinous protein and processing it to a powder form. If hair from the recipient or a compatible doner is used, it is bleached and rinsed, then dried and chopped into about 0.25 inch pieces. The keratinous protein is then homogenized in a solvent to a particular size generally in the range of about 0.1 to about 500 .mu.m. The particles are then ultrasonicated in a solvent. Afterwards, the solvent is evaporated, and the powdered protein is sterilized and suspended in a sterile bioinert solvent to create a protein colloid at a solids concentrations suitable for injection.
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