发明授权
US5369123A Nitrogen-substituted mevinic acid derivatives useful as HMG-CoA
reductase inhibitors
失效
可用作HMG-CoA还原酶抑制剂的氮取代的维甲酸衍生物
- 专利标题： Nitrogen-substituted mevinic acid derivatives useful as HMG-CoA reductase inhibitors
- 专利标题（中）： 可用作HMG-CoA还原酶抑制剂的氮取代的维甲酸衍生物
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申请号： US958849申请日： 1992-10-09
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公开(公告)号： US5369123A公开(公告)日： 1994-11-29
- 发明人: Dinos P. Santafianos , Kathleen M. Poss , Eric M. Gordon , Peggy J. McCann
- 申请人： Dinos P. Santafianos , Kathleen M. Poss , Eric M. Gordon , Peggy J. McCann
- 申请人地址： NJ Princeton
- 专利权人： E. R. Squibb & Sons, Inc.
- 当前专利权人： E. R. Squibb & Sons, Inc.
- 当前专利权人地址： NJ Princeton
- 主分类号： C07C229/46
- IPC分类号： C07C229/46 ; C07C233/81 ; C07C235/14 ; C07C237/12 ; C07C237/38 ; C07C271/24 ; C07C275/26 ; C07C307/08 ; C07D295/155 ; C07D309/30 ; A61K31/40 ; A61K31/365 ; C07C69/74
摘要：
Novel nitrogen-substituted mevinic acid derivatives which inhibit the activity of HMG-CoA reductase. Pharmaceutical compositions, and methods of use for the treatment or prevention of hypercholesterolemia, atherosclerosis, hyperlipoproteinaemia and hyperlipidemia are provided, as are novel methods for preparation and intermediate compounds.