A therapy apparatus has a source of acoustic waves which generates acoustic waves focused onto a focus and which has an x-ray-transparent region, and the focus lying in an isocenter and an x-ray locating system whose central ray proceeds through the isocenter and is adjustable relative to the source in a locating sequence such that a subject to be treated is irradiated by locating radiation from different directions, with the central ray in one of the irradiation directions proceeding through the x-ray transparent region and the acoustic wave source is maintained stationary during the sequence. A corresponding method is also disclosed.