发明授权
- 专利标题： Detection and quantitation method for therapeutic agents in blood
- 专利标题（中）： 血液中治疗剂的检测和定量方法
-
申请号： US41438申请日： 1993-03-31
-
公开(公告)号： US5405782A公开(公告)日： 1995-04-11
- 发明人: Elise C. Kohn , Lance A. Liotta
- 申请人： Elise C. Kohn , Lance A. Liotta
- 申请人地址： DC Washington
- 专利权人： The United States of America as represented by the Secretary of the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Secretary of the Department of Health and Human Services
- 当前专利权人地址： DC Washington
- 主分类号： G01N30/00
- IPC分类号： G01N30/00 ; G01N30/02 ; G01N30/06 ; G01N30/62 ; G01N30/88 ; G01N33/94
摘要：
The present invention relates to an improved method for the determination of therapeutic agents in blood. This method utilizes a solid phase extraction of the solute from plasma followed by reverse phase high performance liquid chromatography on a column of irregularly shaped C-18 modified silica. Comparison of the produced chromatogram with a standard curve provides a precise and accurate quantification of the amount of the solute in blood. Additionally, the extraction and chromatography steps can be readily automated for the rapid determination of multiple samples.
公开/授权文献
信息查询
