发明授权
- 专利标题: Polycyclic and heterocyclic chromophores for bis-imide tumoricidals
- 专利标题(中): 用于双酰亚胺肿瘤的多环和杂环发色团
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申请号: US80862申请日: 1993-06-24
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公开(公告)号: US5416089A公开(公告)日: 1995-05-16
- 发明人: Arthur D. Patten , Gregory Pacofsky , Steven P. Seitz , Emeka A. Akamike , Robert J. Cherney , Robert F. Kaltenbach, III , Michael J. Orwat
- 申请人: Arthur D. Patten , Gregory Pacofsky , Steven P. Seitz , Emeka A. Akamike , Robert J. Cherney , Robert F. Kaltenbach, III , Michael J. Orwat
- 申请人地址: DE Wilmington
- 专利权人: The Du Pont Merck Pharmaceutical Company
- 当前专利权人: The Du Pont Merck Pharmaceutical Company
- 当前专利权人地址: DE Wilmington
- 主分类号: A61K31/435
- IPC分类号: A61K31/435 ; A61P35/00 ; C07D221/18 ; C07D471/06 ; C07D491/06 ; C07D495/06 ; C07D498/06 ; C07D513/06 ; A61K31/47
摘要:
Anticancer compounds of formula I: ##STR1## and pharmaceutically acceptable salts thereof, wherein: R.sup.1, R.sup.2 and R.sup.3 are independently selected H, CH.sub.3, NH.sub.2, NO.sub.2, and CN;R.sup.9 and R.sup.10 are H or alkyl or halo, X.sup.1 and Y.sup.1 or X.sup.2 and Y.sup.2, when present, join together to form, independently, a six membered 1N heterocycle substituted with 1-2 R.sup.3 ; or the group: ##STR2## wherein one of W or Z is C.dbd.O and the other is C.dbd.O, NH, S or O; or when X.sup.2 and Y.sup.2 are not joined together and when R.sup.2 is in the 4-position, then X.sup.2 and R.sup.2 may join together to form an ethylene bridge; are disclosed.
公开/授权文献
- US6051133A Installation apparatus for a roller drive unit 公开/授权日:2000-04-18