发明授权
US5420295A Process for preparing 4,4-dialkyl-6-halo-chromans or thiochromans useful
as pharmaceutical intermediates
失效
制备可用作药物中间体的4,4-二烷基-6-卤代 - 苯并二氢吡喃或二氢色满的方法
- 专利标题： Process for preparing 4,4-dialkyl-6-halo-chromans or thiochromans useful as pharmaceutical intermediates
- 专利标题（中）： 制备可用作药物中间体的4,4-二烷基-6-卤代 - 苯并二氢吡喃或二氢色满的方法
-
申请号： US183543申请日： 1994-01-19
-
公开(公告)号： US5420295A公开(公告)日： 1995-05-30
- 发明人: Michael E. Garst , Lloyd J. Dolby , Nestor A. Fedoruk
- 申请人： Michael E. Garst , Lloyd J. Dolby , Nestor A. Fedoruk
- 申请人地址： CA Irvine
- 专利权人： Allergan, Inc.
- 当前专利权人： Allergan, Inc.
- 当前专利权人地址： CA Irvine
- 主分类号： C07D311/58
- IPC分类号： C07D311/58 ; C07D335/06
摘要：
A process of preparing intermediates useful in making compounds with retinoic acid-like activity is disclosed. The intermediates are halogenated chromans and thiochromans of the formula shown below and are prepared by the alkylation of a phenol or thiophenol with an alkene compound (the starting materials shown in the formula below), cyclization and halogenation. ##STR1## In the formula the symbols have the following meanings: R.sub.1 and R.sub.2 are C.sub.1 to C.sub.4 alkyl, R.sub.3 is H or C.sub.1 to C.sub.4 alkyl, X is oxygen or sulfur, Y is a leaving group, and Z is chlorine, bromine or iodine.