发明授权
- 专利标题： Conformationally restricted angiotensin II antagonists
- 专利标题（中）： 构象上限制的血管紧张素II拮抗剂
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申请号： US127147申请日： 1993-09-24
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公开(公告)号： US5426105A公开(公告)日： 1995-06-20
- 发明人: Robert E. Manning , Horng-Chih Huang
- 申请人： Robert E. Manning , Horng-Chih Huang
- 申请人地址： IL Skokie
- 专利权人： G.D. Searle & Co.
- 当前专利权人： G.D. Searle & Co.
- 当前专利权人地址： IL Skokie
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; C07D471/04 ; C07D487/04 ; A61K31/435
摘要：
Conformationally restricted compounds are described which are therapeutically effective as angiotensin II antagonists for the treatment of circulatory disorders. Compounds of particular interest are of Formula I ##STR1## wherein W is N or CH.sub.2 ; wherein X is N or CR.sup.2 ; wherein Y is (CH.sub.2).sub.n and n is 1 to 3; wherein Z is C.dbd.R.sup.3 or CR.sup.4 R.sup.5, or wherein Y and Z together forms --CR.sup.6 .dbd.CR.sup.7 --, --CR.sup.6 .dbd.CR.sup.7 --CH.sub.2 or --CR.sup.6 .dbd.CR.sup.7 --CH.sub.2 --CH.sup.2 --; wherein the remainder of the variables are as defined in the specification; or a pharmaceutically suitable salt or tautomer thereof.
公开/授权文献
- US5992023A Shear with interchangeable wear parts 公开/授权日：1999-11-30
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