发明授权
US5428060A Heteroarylnaphthalene lactones as inhibitors of leukotriene biosynthesis
失效
杂芳基萘内酯作为白三烯生物合成的抑制剂
- 专利标题： Heteroarylnaphthalene lactones as inhibitors of leukotriene biosynthesis
- 专利标题（中）： 杂芳基萘内酯作为白三烯生物合成的抑制剂
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申请号： US936809申请日： 1992-08-27
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公开(公告)号： US5428060A公开(公告)日： 1995-06-27
- 发明人: Yves Ducharme , John W. Gillard , Rejean Fortin , Daniel Dube , Yves Girard , Pierre Hamel , Daniel Delorme
- 申请人： Yves Ducharme , John W. Gillard , Rejean Fortin , Daniel Dube , Yves Girard , Pierre Hamel , Daniel Delorme
- 申请人地址： CAX Kirkland
- 专利权人： Merck Frosst Canada, Inc.
- 当前专利权人： Merck Frosst Canada, Inc.
- 当前专利权人地址： CAX Kirkland
- 主分类号： C07D405/14
- IPC分类号： C07D405/14 ; C07D407/14 ; C07D409/14 ; C07D493/08 ; A61K31/36 ; A61K31/365
摘要：
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.