发明授权
- 专利标题： Isatineoxime derivatives, their preparation and use
- 专利标题（中）： 异恶嗪衍生物，其制备和用途
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申请号： US088328申请日： 1993-07-07
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公开(公告)号： US5436250A公开(公告)日： 1995-07-25
- 发明人: Frank Watjen , Bjarne H. Dahl , Jorgen Drejer , Lein H. Jensen
- 申请人： Frank Watjen , Bjarne H. Dahl , Jorgen Drejer , Lein H. Jensen
- 申请人地址： DKX Glostrup
- 专利权人： NeuroSearch A/S
- 当前专利权人： NeuroSearch A/S
- 当前专利权人地址： DKX Glostrup
- 主分类号： C07C205/45
- IPC分类号： C07C205/45 ; C07D471/04 ; C07D487/04 ; C07D491/04 ; C07D491/048 ; C07D495/04 ; A61K31/395
摘要：
A compound having the formula ##STR1## wherein R.sup.4 and R.sup.5 independently are hydrogen, halogen, CF.sub.3, CN, NO.sub.2 or SO.sub.2 NR.sup.1 R.sup.2 whereinR.sup.1 is hydrogen or C.sub.1-6 -alkyl which may be straight, branched or cyclic,R.sup.2 is hydrogen or C.sub.1-6 -alkyl which may be straight, branched or cyclic, or wherein R.sup.1 and R.sup.2 together represent --(CH.sub.2).sub.n --A--(CH.sub.2).sub.m --, wherein A is O, S, CH.sub.2 or NR.sup.I, wherein R.sup.I is H, C.sub.1-6 -alkyl which may be straight, branched or cyclic, n is 0, 1, 2, 3, 4, 5 and m is 0, 1, 2, 3, 4, 5;R.sup.II is hydrogen, benzyl, (C.dbd.O)CF.sub.3, C.sub.1-6 -carboxylic acid acyl, C.sub.1-6 -alkoxy which may be branched or cyclic, or C.sub.1-6 -alkyl which may be straight, branched or cyclic, CH.sub.2 CO.sub.2 R.sup.VI wherein R.sup.VI is hydrogen or C.sub.1-6 -alkyl which may be straight or branched;and a method of treating disorders of a mammal, including a human, responsive to the blockade of glutamic and aspartic acid receptors, with the same.
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