A probe for translumenal circumferential delivery of energy through a biological lumen comprises a catheter which is constructed and arranged to be placed within a particular biological lumen. A plurality of guide channels are formed within the catheter extending from near the proximal end to near the distal end of the catheter. The guide channels include respective diverting regions near the distal end which bend radially toward the circumference of the catheter. Energy delivery devices, such as optical fibers or electrical conductors, are placed within the guide channels and transmit energy to the distal end of the device. The energy delivery devices have relatively flexible portions near the distal ends such that when extended through the diverting region of the guide channels they are deflected radially in a direction to intersect the circumference of the biological lumen. An adaptor is coupled with the energy delivery device to supply energy for transmission to the tissue at the distal end of the device. Thus, the energy delivery device may be positioned in a withdrawn position in the catheter so that the distal end of the energy delivery device lies within the guide channel, and in an extended position so that the distal end of the energy delivery device is diverted by the diverting region of the guide channel and extends into the tissue to be treated.