发明授权
- 专利标题： Platelet activating factor antagonists
- 专利标题（中）： 血小板激活因子拮抗剂
-
申请号： US162034申请日： 1993-12-02
-
公开(公告)号： US5459152A公开(公告)日： 1995-10-17
- 发明人: James B. Summers , Steven K. Davidsen , James H. Holms , Daisy Pireh , H. Robin Heyman , Michael B. Martin , Douglas H. Steinman , George S. Sheppard , George M. Carrera, Jr.
- 申请人： James B. Summers , Steven K. Davidsen , James H. Holms , Daisy Pireh , H. Robin Heyman , Michael B. Martin , Douglas H. Steinman , George S. Sheppard , George M. Carrera, Jr.
- 申请人地址： IL Abbott Park
- 专利权人： Abbott Laboratories
- 当前专利权人： Abbott Laboratories
- 当前专利权人地址： IL Abbott Park
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; A61K31/4406 ; A61K49/00 ; A61K49/06 ; A61P1/04 ; A61P7/02 ; A61P7/06 ; A61P9/02 ; A61P11/06 ; A61P17/06 ; A61P29/00 ; A61P37/06 ; A61P37/08 ; A61P43/00 ; C07B47/00 ; C07D213/69 ; C07D487/04 ; C07D498/04 ; C07D513/04 ; C07F5/00 ; C07F13/00
摘要：
Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
公开/授权文献
信息查询
