Invention Grant
- Patent Title: Platelet activating factor antagonists
- Patent Title (中): 血小板激活因子拮抗剂
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Application No.: US162034Application Date: 1993-12-02
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Publication No.: US5459152APublication Date: 1995-10-17
- Inventor: James B. Summers , Steven K. Davidsen , James H. Holms , Daisy Pireh , H. Robin Heyman , Michael B. Martin , Douglas H. Steinman , George S. Sheppard , George M. Carrera, Jr.
- Applicant: James B. Summers , Steven K. Davidsen , James H. Holms , Daisy Pireh , H. Robin Heyman , Michael B. Martin , Douglas H. Steinman , George S. Sheppard , George M. Carrera, Jr.
- Applicant Address: IL Abbott Park
- Assignee: Abbott Laboratories
- Current Assignee: Abbott Laboratories
- Current Assignee Address: IL Abbott Park
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K31/4406 ; A61K49/00 ; A61K49/06 ; A61P1/04 ; A61P7/02 ; A61P7/06 ; A61P9/02 ; A61P11/06 ; A61P17/06 ; A61P29/00 ; A61P37/06 ; A61P37/08 ; A61P43/00 ; C07B47/00 ; C07D213/69 ; C07D487/04 ; C07D498/04 ; C07D513/04 ; C07F5/00 ; C07F13/00
Abstract:
Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
Public/Granted literature
- US6112720A Method of tuning hydraulically-actuated fuel injection systems based on electronic trim Public/Granted day:2000-09-05
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