发明授权
US5462726A Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A.sub.2 receptor antagonist and pharmaceutical compositions containing such solvents 失效
使用血栓素A2受体拮抗剂抑制含有蓖麻油酸或蓖麻油或其衍生物的溶剂的副作用的方法和含有这些溶剂的药物组合物

  • 专利标题: Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A.sub.2 receptor antagonist and pharmaceutical compositions containing such solvents
  • 专利标题(中): 使用血栓素A2受体拮抗剂抑制含有蓖麻油酸或蓖麻油或其衍生物的溶剂的副作用的方法和含有这些溶剂的药物组合物
  • 申请号: US168348
    申请日: 1993-12-17
  • 公开(公告)号: US5462726A
    公开(公告)日: 1995-10-31
  • 发明人: Nicholas J. Lodge
  • 申请人: Nicholas J. Lodge
  • 申请人地址: NJ Princeton
  • 专利权人: Bristol-Myers Squibb Company
  • 当前专利权人: Bristol-Myers Squibb Company
  • 当前专利权人地址: NJ Princeton
  • 主分类号: A61K9/00
  • IPC分类号: A61K9/00 A61K31/422 A61K31/64 A61K38/13 A61K47/44 A61K49/00
Method of inhibiting side effects of solvents containing ricinoleic acid
or castor oil or derivatives thereof employing a thromboxane A.sub.2
receptor antagonist and pharmaceutical compositions containing such
solvents
摘要:
A method is provided for inhibiting or preventing toxicity and other unwanted effects (a) caused by solvents for pharmaceuticals which solvents contain castor oil or ricinoleic acid or derivatives thereof, such as Cremophor, or (b) caused by a drug, such as cyclosporine A, dissolved or suspended in solvents such as ricinoleic acid or castor oil or derivative thereof, employing a thromboxane A.sub.2 receptor antagonist. Solvent compositions containing ricinoleic acid or castor oil or derivatives thereof and a thromboxane A.sub.2 receptor antagonist, and pharmaceutical compositions including a drug, solvent containing ricinoleic acid or castor oil or derivative thereof, and a thromboxane A.sub.2 receptor antagonist are also provided.
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