发明授权
- 专利标题： Process for preparing 2', 3'- dideoxyinosine
- 专利标题（中）： 制备2'，3'-二脱氧肌苷的方法
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申请号： US860605申请日： 1992-03-30
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公开(公告)号： US5466793A公开(公告)日： 1995-11-14
- 发明人: Yutaka Honda , Hiroshi Shiragami , Hisao Iwagami , Masayuki Arai
- 申请人： Yutaka Honda , Hiroshi Shiragami , Hisao Iwagami , Masayuki Arai
- 申请人地址： JPX Kawasaki
- 专利权人： Ajinomoto Co., Inc.
- 当前专利权人： Ajinomoto Co., Inc.
- 当前专利权人地址： JPX Kawasaki
- 优先权： JPX48425 19880301; JPX170963 19880711; JPX310131 19881209; JPX320046 19881219
- 主分类号： C07H19/04
- IPC分类号： C07H19/04 ; C07H19/06 ; C07H19/16 ; C07H19/173 ; C07H19/073
摘要：
A process for preparing 2',3'-dideoxyinosine comprising reducing a nucleoside of the formula IIIa or IIIb ##STR1## wherein R.sup.2 is hydrogen, C.sub.1-12 acyl, C.sub.1-12 alkyl, C.sub.7-8 aralkyl or a silyl protecting group; X is Cl, Br, or I; R.sub.5 is C.sub.1-12 acyl; H.sub.x is hypoxanthine; with hydrogen in the presence of a palladium catalyst; wherein said reduction is conducted in a solvent containing a base of pH 9-11 and wherein the solvent is acetonitrile, aqueous acetonitrile, aqueous ethyl acetate, or aqueous methanol.
公开/授权文献
- US5875962A Dispenser carton box 公开/授权日：1999-03-02
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