Invention Grant
US5472683A Nanoparticulate diagnostic mixed carbamic anhydrides as X-ray contrast
agents for blood pool and lymphatic system imaging
失效
纳米颗粒诊断混合氨基酸酐作为血液池和淋巴系统成像的X射线造影剂
- Patent Title: Nanoparticulate diagnostic mixed carbamic anhydrides as X-ray contrast agents for blood pool and lymphatic system imaging
- Patent Title (中): 纳米颗粒诊断混合氨基酸酐作为血液池和淋巴系统成像的X射线造影剂
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Application No.: US401570Application Date: 1995-03-09
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Publication No.: US5472683APublication Date: 1995-12-05
- Inventor: Carl R. Illig
- Applicant: Carl R. Illig
- Applicant Address: NY Rochester
- Assignee: Eastman Kodak Company
- Current Assignee: Eastman Kodak Company
- Current Assignee Address: NY Rochester
- Main IPC: A61K49/04
- IPC: A61K49/04 ; C07C271/12 ; C07C271/22 ; C07C271/28 ; C07J41/00 ; C07C271/02
Abstract:
This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen, and/or lymph system of a mammal comprising administering a contrast effective amount of a mixed carbamic anhydride as a contrast agent having the structure ##STR1## X is H, NR.sup.1 R.sup.2 or CONR.sup.1 R.sup.3, R.sup.1 is H or alkylR.sup.2 is COR.sup.3R.sup.3 is H, alkyl or arylY is NR.sup.1 R.sup.2 or CONR.sup.1 R.sup.3 andN is NR.sup.1 R.sup.4 andR.sup.4 is H, alkyl, aryl or CH(R.sup.5)CO.sub.2 R.sup.1.This invention further relates to novel mixed carbamic anhydride contrast agents having the above structure to x-ray contrast compositions comprising such agents, and to methods of x-ray diagnostic imaging utilizing such agents.
Public/Granted literature
- US5075453A Process for producing aryloxy-substituted phosphazene derivatives Public/Granted day:1991-12-24
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