Invention Grant
US5472976A Poly 4-aminopyrrole-2-carboxyamide derivatives, and pharmaceutical
compositions which contain them
失效
聚4-氨基吡咯-2-甲酰胺衍生物和含有它们的药物组合物
- Patent Title: Poly 4-aminopyrrole-2-carboxyamide derivatives, and pharmaceutical compositions which contain them
- Patent Title (中): 聚4-氨基吡咯-2-甲酰胺衍生物和含有它们的药物组合物
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Application No.: US109932Application Date: 1993-08-06
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Publication No.: US5472976APublication Date: 1995-12-05
- Inventor: Fabio Animati , Federico Arcamone , Giuseppe Giannini , Paolo Lombardi
- Applicant: Fabio Animati , Federico Arcamone , Giuseppe Giannini , Paolo Lombardi
- Applicant Address: ITX Florence ITX Rome
- Assignee: A. Menarini Industrie Farmaceutiche Riunite S.r.l.,Bristol-Meyers Squibb S.p.A.
- Current Assignee: A. Menarini Industrie Farmaceutiche Riunite S.r.l.,Bristol-Meyers Squibb S.p.A.
- Current Assignee Address: ITX Florence ITX Rome
- Priority: ITXMI91A0404 19910215
- Main IPC: A61K31/40
- IPC: A61K31/40 ; A61P31/12 ; A61P35/00 ; C07D207/34 ; C07D207/30
Abstract:
This invention relates to polyaminopyrrolecarboxyamide derivatives of general formula (I) and their pharmaceutically acceptable salts, in which A represents a chemical bond or an aromatic or heteroaromatic radical, and:if A is a chemical bond, R is hydrogen, alkyl, dialkylaminoalkyl, alkenyl, cycloalkyl, arylalkyl, arylalkenyl, haloalkyl, or an aromatic or heteroaromatic radical;whereas if A is an aromatic or heteroaromatic radical, R is nitro, amino or formylamino;n is 0 or a whole number between 1 and 4;Z is an alkylene or aromatic radical. ##STR1##
Abstract(Chinese):
本发明涉及通式（I）的聚氨基吡咯酰胺酰胺衍生物及其药学上可接受的盐，其中A表示化学键或芳族或杂芳族基团，以及：如果A是化学键，则R是氢，烷基，二烷基氨基烷基，烯基 ，环烷基，芳基烷基，芳基烯基，卤代烷基或芳族或杂芳族基团; 而如果A是芳族或杂芳族基团，则R是硝基，氨基或甲酰氨基; n为0或1〜4之间的整数; Z是亚烷基或芳族基团。 （1）+ TR
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