发明授权
US5476765A Synthetic peptide compositions with immunoreactivities to antibodies to
HTLV and as vaccines
失效
具有对HTLV抗体和疫苗的免疫反应性的合成肽组合物
- 专利标题： Synthetic peptide compositions with immunoreactivities to antibodies to HTLV and as vaccines
- 专利标题（中）： 具有对HTLV抗体和疫苗的免疫反应性的合成肽组合物
-
申请号： US901874申请日： 1992-06-22
-
公开(公告)号： US5476765A公开(公告)日： 1995-12-19
- 发明人: Chang Y. Wang
- 申请人： Chang Y. Wang
- 申请人地址： NY Hauppauge
- 专利权人： United Biomedical, Inc.
- 当前专利权人： United Biomedical, Inc.
- 当前专利权人地址： NY Hauppauge
- 主分类号： C07K14/15
- IPC分类号： C07K14/15 ; G01N33/53
摘要：
The present invention relates to a method for the detection HTLV-I and/or HTLV-II reactive antibodies and diagnosis of ATL (adult T cell leukemia/lymphoma) condition by the use of chemically synthesized peptide compositions. The peptide compositions comprise peptides having amino acid sequences corresponding to transmembrane and external segments of the envelope protein of HTLV-I/HTLV-II and mixtures thereof. The peptide compositions are highly immunoreactive with antibodies to HTLV in sera. The present invention further relates to a method for the simultaneous detection and diagnosis of ATL, HTLV-I and/or HTLV-II infection and Acquired Immune Deficiency Syndrome (AIDS) by the use of chemically synthesized HTLV peptide compositions in conjunction with a chemically synthesized HIV (1 and 2) peptide composition. The present invention also provides a simple method to differentiate between HTLV-I and HTLV-II infections.The detection method includes an enzyme-linked immunosorbent assay (ELISA), an immunoradiometric assay (IRMA), and other forms of immunoassay procedures such as enzyme immuno blotting assay on nitrocellulose paper and an agglutination assay using the peptide composition as the antigen. The preferred detection method is ELISA.
公开/授权文献
信息查询
