发明授权
- 专利标题： 3-hydroxypyridin-4-one derivatives as chelating agents
- 专利标题（中）： 3-羟基吡啶-4-酮衍生物作为螯合剂
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申请号： US204202申请日： 1994-03-07
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公开(公告)号： US5480894A公开(公告)日： 1996-01-02
- 发明人: Robert C. Hider , Surinder Singh , Gary S. Tilbrook , Paul S. Dobbin
- 申请人： Robert C. Hider , Surinder Singh , Gary S. Tilbrook , Paul S. Dobbin
- 申请人地址： GBX London
- 专利权人： British Technology Group Limited
- 当前专利权人： British Technology Group Limited
- 当前专利权人地址： GBX London
- 优先权： GBX9217099 19920812
- 主分类号： C07D213/65
- IPC分类号： C07D213/65 ; A61K31/44 ; A61K31/4418 ; A61K31/4425 ; A61P39/02 ; C07D213/69 ; C09K3/00 ; C07D211/74
摘要：
3-Hydroxypyridin-4-ones of formula (I) ##STR1## in which R.sub.1 is a methyl, ethyl, 2-(.alpha.-methylpropionyloxy)ethyl or 2-pivoloyloxyethyl group and R.sub.2, R.sub.3 and R.sub.4 are each separately selected from hydrogen and methyl, ethyl, 2-(.alpha.-methylpropionyloxy)ethyl and 2-pivaloyloxyethyl groups with the provisos that (a) one only of R.sub.1 to R.sub.4 is either a 2-(.alpha.-methylpropionyloxy)ethyl group or a 2-pivaloyloxyethyl group, (b) at least one of R.sub.2 and R.sub.3 is other than hydrogen and (c) the total number of carbon atoms in R.sub.1 to R.sub.4 is no more than eleven, and physiologically acceptable salts thereof are of use in therapy, particularly in the treatment of conditions in which there is a toxic concentration of a metal, for example iron, in the body.
公开/授权文献
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