发明授权
US5481011A Process for preparing N-protected amino acid .alpha.-halomethyl ketones
and alcohols from N-protected amino acid esters
失效
从N-保护的氨基酸酯制备N-保护的氨基酸的α-卤甲基酮和醇的方法
- 专利标题： Process for preparing N-protected amino acid .alpha.-halomethyl ketones and alcohols from N-protected amino acid esters
- 专利标题（中）： 从N-保护的氨基酸酯制备N-保护的氨基酸的α-卤甲基酮和醇的方法
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申请号： US355373申请日： 1994-12-13
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公开(公告)号： US5481011A公开(公告)日： 1996-01-02
- 发明人: Ping Chen , Peter T. W. Cheng , Steven H. Spergel , Joel C. Barrish , John K. Thottathil , Robert Zahler , Richard P. Polniaszek , Xuebao Wang
- 申请人： Ping Chen , Peter T. W. Cheng , Steven H. Spergel , Joel C. Barrish , John K. Thottathil , Robert Zahler , Richard P. Polniaszek , Xuebao Wang
- 申请人地址： NY New York
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： NY New York
- 主分类号： C07D301/24
- IPC分类号： C07D301/24 ; C07C269/06 ; C07C271/18 ; C07D303/36 ; C07D301/02 ; C07D303/12
摘要：
The present invention relates to a novel method useful for the conversion of amino acids to halomethylketones, which are then converted to amino acid epoxides. Such epoxides are important intermediates for the synthesis of inhibitors of renin and HIV protease, which are particularly useful in the treatment and/or prevention of HIV infection (AIDS).
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