发明授权
US5484937A N-substituted N-(.alpha.-triazolyl-toluyl)pyrrole compounds for
treatment of circulatory disorders
失效
用于治疗循环障碍的N-取代的N-(α-三唑基 - 甲苯酰基)吡咯化合物
- 专利标题: N-substituted N-(.alpha.-triazolyl-toluyl)pyrrole compounds for treatment of circulatory disorders
- 专利标题(中): 用于治疗循环障碍的N-取代的N-(α-三唑基 - 甲苯酰基)吡咯化合物
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申请号: US117269申请日: 1993-09-07
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公开(公告)号: US5484937A公开(公告)日: 1996-01-16
- 发明人: Philippe R. Bovy , David B. Reitz , Robert E. Manning
- 申请人: Philippe R. Bovy , David B. Reitz , Robert E. Manning
- 申请人地址: IL Chicago
- 专利权人: G.D. Searle & Co.
- 当前专利权人: G.D. Searle & Co.
- 当前专利权人地址: IL Chicago
- 主分类号: C07D521/00
- IPC分类号: C07D521/00 ; C07D403/10 ; A61K31/41
摘要:
A class of N-substituted N-(.alpha.-triazolyltoluyl)pyrrole compounds described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula ##STR1## wherein m is one; wherein R.sup.1 is selected from alkyl; and wherein R.sup.2 is selected from alkyl; and wherein each of R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9 and R.sup.10 is independently selected from hydrido, halo, nitro, trifluoromethyl, hydroxy, alkoxy, cyano, carboxyl and methoxycarbonyl; with the proviso that at least one of R.sup.5 and R.sup.8 must be selected from COOH, SH, PO.sub.3 H.sub.2, SO.sub.3 H, CONHNH.sub.2, CONHNHSO.sub.2 CF.sub.3, OH, ##STR2## wherein each of R.sup.42 and R.sup.43 is independently selected from chloro, cyano, nitro, trifluoromethyl, methoxycarbonyl and trifluoromethylsulfonyl; or a tautomer thereof or a pharmaceutically-acceptable salt thereof. These compounds are particularly useful in treatment or control of hypertension and congestive heart failure.
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