In an endoscope system including an endoscope having an insertion section insertable into a cavity under inspection and an operation section to which a proximal end of the insertion section is connected, and a disposable protection cover having an insertion section cover for covering the insertion section of the endoscope and an operation section cover for covering said operation section of the endoscope, said operation section cover is constructed such that it can be commonly used to cover operation sections of a plurality of endoscopes. Upon removing the insertion section of the endoscope from the insertion section cover, the insertion section section cover is supported by a supporting apparatus including a proximal end supporting unit for supporting a proximal end of the insertion section cover and a distal end supporting unit for supporting a distal end of the insertion section cover. The contaminated insertion section cover can be supported by the supporting apparatus such that the insertion section cover is brought into contact with a floor on an examination room.