发明授权
US5492688A Metered dose inhaler fomulations which include the ozone-friendly
propellant HFC 134a and a pharmaceutically acceptable suspending,
solubilizing, wetting, emulsifying or lubricating agent
失效
计量剂量吸入器制剂，其包括适用于臭氧的推进剂HFC 134a和药学上可接受的悬浮剂，增溶剂，润湿剂，乳化剂或润滑剂
- 专利标题： Metered dose inhaler fomulations which include the ozone-friendly propellant HFC 134a and a pharmaceutically acceptable suspending, solubilizing, wetting, emulsifying or lubricating agent
- 专利标题（中）： 计量剂量吸入器制剂，其包括适用于臭氧的推进剂HFC 134a和药学上可接受的悬浮剂，增溶剂，润湿剂，乳化剂或润滑剂
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申请号： US217012申请日： 1994-03-23
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公开(公告)号： US5492688A公开(公告)日： 1996-02-20
- 发明人: Peter R. Byron , Frank E. Blondino
- 申请人： Peter R. Byron , Frank E. Blondino
- 申请人地址： VA Herndon VA Richmond
- 专利权人： The Center for Innovative Technology,Virginia Commonwealth University
- 当前专利权人： The Center for Innovative Technology,Virginia Commonwealth University
- 当前专利权人地址： VA Herndon VA Richmond
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; A61K9/12
摘要：
Metered dose inhaler (MDI) formulations which utilize 1,1,1,2-tetrafluoroethane (HFC 134a) as the sole propellant are made practical by including a polar surfactant such as polyethylene glycol, diethylene glycol monoethyl ether, polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan monooleate, propoxylated polyethylene glycol, and polyoxyethylene (4) lauryl ether for suspending, solubilizing, wetting and emulsifying the drug constituent and lubricating the valve components of the MDI.
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