A manually-operated wheelchair is disclosed, which includesa frame to which two front wheels and two rear wheels are fastened pivotally, wherein the frame is provided respectively on both left and right sides thereof with a horizontal fixation rod; anda connection rod control mechanism provided respectively on both left and right sides of the frame containing a coupling rod, an operating rod fastened at one end thereof with the coupling rod, a crank fastened pivotally at one end thereof with the coupling rod and at another end thereof with the horizontal fixation rod, a rocking rod fastened pivotally at one end thereof with the coupling rod and at another end thereof with the horizontal fixation rod, a transmission wheel which is mounted on a pivoting point of the fixation rod and the crank and is fastened securely with the crank such that the transmission wheel and the crank can be actuated synchronously, and a transmission chain-connecting the transmission wheel to an axle of the front wheel for transmitting motion from the transmission wheel to the front wheel.