发明授权
- 专利标题： Compounds that inhibit complement and/or suppress immune activity
- 专利标题（中）： 抑制补体和/或抑制免疫活性的化合物
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申请号： US87676申请日： 1994-01-21
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公开(公告)号： US5506247A公开(公告)日： 1996-04-09
- 发明人: Robert D. Sindelar , Barton J. Bradbury , Teodoro S. Kaufman , Stephen H. Ip , Henry C. Marsh, Jr. , Chew Lee
- 申请人： Robert D. Sindelar , Barton J. Bradbury , Teodoro S. Kaufman , Stephen H. Ip , Henry C. Marsh, Jr. , Chew Lee
- 申请人地址： MA Needham MS University
- 专利权人： T Cell Sciences, Inc.,The University of Mississippi
- 当前专利权人： T Cell Sciences, Inc.,The University of Mississippi
- 当前专利权人地址： MA Needham MS University
- 主分类号： C07D307/94
- IPC分类号： C07D307/94 ; A61K31/42 ; A61K31/41
摘要：
The present invention is directed to compounds which suppress immune responses and/or selectively inhibit complement. These compounds contain an aromatic ring and are substituted dihydrobenzofurans, spirobenzofuran-2(3H)-cycloalkanes, and their open chain intermediates. The compounds of the present invention, and the pharmaceutically acceptable salts thereof, interrupt the proteolytic processing of C5 to bioactive components, exhibit immunosuppressive activities, and have therapeutic utility in the amelioration of disease and disorders mediated by complement and/or immune activity.
公开/授权文献
- US5915608A Shoulder strap buffering device of shoulder bag 公开/授权日：1999-06-29