发明授权
US5506261A Substituted aryl- and heteroarylalkenyl-N-hydroxyurea inhibitors of
leukotriene biosynthesis
失效
白三烯生物合成的取代芳基 - 和杂芳基烯基-N-羟基脲抑制剂
- 专利标题: Substituted aryl- and heteroarylalkenyl-N-hydroxyurea inhibitors of leukotriene biosynthesis
- 专利标题(中): 白三烯生物合成的取代芳基 - 和杂芳基烯基-N-羟基脲抑制剂
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申请号: US239648申请日: 1994-05-09
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公开(公告)号: US5506261A公开(公告)日: 1996-04-09
- 发明人: Dee W. Brooks , Andrew O. Stewart , Richard A. Craig
- 申请人: Dee W. Brooks , Andrew O. Stewart , Richard A. Craig
- 申请人地址: IL Abbott Park
- 专利权人: Abbott Laboratories
- 当前专利权人: Abbott Laboratories
- 当前专利权人地址: IL Abbott Park
- 主分类号: C07D277/22
- IPC分类号: C07D277/22 ; C07D277/28 ; C07D307/52 ; C07D333/20 ; C07D409/06 ; C07D417/06 ; C07D333/32 ; A61K31/38 ; A61K31/385 ; C07D333/34
摘要:
Compounds of the structure ##STR1## wherein Z is selected from optionally substituted thienyl, thiazolyl, oxazolyl and furyl are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.
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