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US5506261A Substituted aryl- and heteroarylalkenyl-N-hydroxyurea inhibitors of leukotriene biosynthesis 失效
白三烯生物合成的取代芳基 - 和杂芳基烯基-N-羟基脲抑制剂

Substituted aryl- and heteroarylalkenyl-N-hydroxyurea inhibitors of
leukotriene biosynthesis
摘要:
Compounds of the structure ##STR1## wherein Z is selected from optionally substituted thienyl, thiazolyl, oxazolyl and furyl are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.
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