发明授权
- 专利标题: Derivatives of perhydroisoindole and preparation thereof
- 专利标题(中): 全氢异吲哚的衍生物及其制备
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申请号: US146142申请日: 1993-11-17
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公开(公告)号: US5508433A公开(公告)日: 1996-04-16
- 发明人: Daniel Achard , Serge Grisoni , Stephen Hanessian , Claude Moutonnier , Jean-Francois Peyronel , Michel Tabart , Alain Truchon
- 申请人: Daniel Achard , Serge Grisoni , Stephen Hanessian , Claude Moutonnier , Jean-Francois Peyronel , Michel Tabart , Alain Truchon
- 申请人地址: FRX Antony
- 专利权人: Rhone-Poulenc Rorer S.A.
- 当前专利权人: Rhone-Poulenc Rorer S.A.
- 当前专利权人地址: FRX Antony
- 优先权: FRX9106036 19910517
- 主分类号: C07D209/44
- IPC分类号: C07D209/44 ; C07D209/48
摘要:
This invention relates to derivatives of perhydroisoindol of formula: ##STR1## in which the radicals R are hydrogen atoms or together form a bond, the symbols R.sub.2 are phenyl radicals which can be substituted by a halogen atom or a methyl radical in position 2 or 3, R.sub.3 is a halogen atom or a hydroxy radical, R.sub.4 is H or halogen if R.sub.3 is halogen, in their isomer forms, or mixture thereof, and possibly also their salts when they exist, and preparation thereof. The derivatives of the invention are particularly interesting as P substance antagonist.
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