发明授权
US5510340A Antihypercholesterolemic compounds and related pharmaceutical
compositions and methods of use
失效
抗高血胆固醇化合物及其相关药物组合物和使用方法
- 专利标题： Antihypercholesterolemic compounds and related pharmaceutical compositions and methods of use
- 专利标题（中）： 抗高血胆固醇化合物及其相关药物组合物和使用方法
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申请号： US898934申请日： 1992-06-12
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公开(公告)号： US5510340A公开(公告)日： 1996-04-23
- 发明人: Wesley K. M. Chong , Wan-Ru Chao , Dennis M. Yasuda , John G. Johansson , Mitchell A. Avery , Masato Tanabe
- 申请人： Wesley K. M. Chong , Wan-Ru Chao , Dennis M. Yasuda , John G. Johansson , Mitchell A. Avery , Masato Tanabe
- 申请人地址： CA Menlo Park
- 专利权人： SRI International
- 当前专利权人： SRI International
- 当前专利权人地址： CA Menlo Park
- 主分类号： A61K31/58
- IPC分类号： A61K31/58 ; A61K31/567 ; A61K31/575 ; A61P3/00 ; A61P3/06 ; A61P9/10 ; C07D261/20 ; C07J3/00 ; C07J7/00 ; C07J9/00 ; C07J31/00 ; C07J53/00 ; C07J71/00
摘要：
Novel antihypercholesterolemic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R is a C-17 side chain, R.sup.1 is --OH, .dbd.O, or the like, and X and Y are N, N.fwdarw.O, CH, C--OH, C--OCH.sub.3 or C--Z. Methods of using the compound of formula (I) or other novel oxysterol analogs to treat hypercholesterolemia are provided, as are pharmaceutical compositions containing the compounds.
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