Invention Grant
- Patent Title: 2-arylamidothiazole derivatives with CNS activity
- Patent Title (中): 具有CNS活性的2-芳基氨基噻唑衍生物
-
Application No.: US347524Application Date: 1994-11-30
-
Publication No.: US5510478APublication Date: 1996-04-23
- Inventor: Annmarie L. Sabb
- Applicant: Annmarie L. Sabb
- Applicant Address: NJ Madison
- Assignee: American Home Products Corporation
- Current Assignee: American Home Products Corporation
- Current Assignee Address: NJ Madison
- Main IPC: C07D277/46
- IPC: C07D277/46 ; C07D277/56 ; C07D417/12 ; C07D453/02 ; C07D417/06 ; C07D417/14
Abstract:
The compound of the formula: ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are, independently, H, alkyl, halo, perhaloalkyl, hydroxy, alkoxy, aryl or arylalkyl; n is an integer from 0-5; R is azabicyclo 2.2.2!octyl or azabicyclo 2.2.1!heptyl when n.sub.1 is zero, or R is NR.sub.4 R.sub.5 when n.sub.1 is 1, 2, 3, 4, or 5, in which R.sub.4 and R.sub.5 are alkyl or R.sub.4 and R.sub.5, taken with the nitrogen atom to which they are attached, are N-(substituted aryl)piperazinyl in which said substituent is alkoxy, halo, or perhaloalkyl; N-(pyridyl)piperazinyl; N-(pyrimidinyl)piperazinyl; or 3-azabicyclo- 3.2.2!non-3-yl; X is oxygen or NH; n and n.sub.1 are, independently, one of the integers 0, 1, 2, 3, 4 or 5; or a pharmaceutically acceptable salt thereof are centrally active muscarinic agents.
Public/Granted literature
- US6148956A Resonator with high heat resistance Public/Granted day:2000-11-21
Information query