发明授权
- 专利标题： Ester of L-carnitine with gamma-hydroxybutyric acid and pharmaceutical compositions containing it for inhibiting neuronal degeneration and for the treatment of coma
- 专利标题（中）： 含有γ-羟基丁酸的左旋肉碱酯和含有它用于抑制神经元变性和治疗昏迷的药物组合物
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申请号： US412858申请日： 1995-03-29
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公开(公告)号： US5547986A公开(公告)日： 1996-08-20
- 发明人: Maria O. Tinti , Domenico Misiti , Claudio Cavazza
- 申请人： Maria O. Tinti , Domenico Misiti , Claudio Cavazza
- 申请人地址： ITX Rome
- 专利权人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 当前专利权人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 当前专利权人地址： ITX Rome
- 优先权： ITX48475/89 19891020
- 主分类号： A61K31/19
- IPC分类号： A61K31/19 ; A61K31/205 ; A61P25/26 ; A61P25/28 ; C07C229/22 ; A61K31/225
摘要：
The L-carnitine ester with gamma-hydroxybutyric acid and its pharmacologically acceptable salts of formula (I) ##STR1## wherein X.sup.- is the anion of a pharmacologically acceptable salt, e.g. chloride, bromide, orotate, acid aspartate, acid citrate, acid phosphate, acid fumarate, lactate, acid maleate, acid oxalate, acid sulfate and glucosephosphate are active in inhibiting neuronal degeneration (as it occurs in Alzheimer's senile dementia and Parkinson's disease) and in the treatment of coma.