发明授权
- 专利标题： Azabicyclic compounds as 5-HT4 receptor antagonists
- 专利标题（中）： 氮杂环化合物作为5-HT 4受体拮抗剂
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申请号： US204428申请日： 1994-11-14
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公开(公告)号： US5552398A公开(公告)日： 1996-09-03
- 发明人: Francis D. King , Laramie M. Gaster , Paul A. Wyman
- 申请人： Francis D. King , Laramie M. Gaster , Paul A. Wyman
- 申请人地址： GB2 Brentford
- 专利权人： SmithKline Beecham p.l.c.
- 当前专利权人： SmithKline Beecham p.l.c.
- 当前专利权人地址： GB2 Brentford
- 优先权： GBX9119449 19910912; GBX9122474 19911023; GBX9201413 19920123; GBX9206075 19920320
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K31/435 ; A61K31/55 ; A61P9/06 ; A61P43/00 ; C07D405/12 ; C07D413/04 ; C07D413/12 ; C07D455/02 ; C07D471/04 ; C07D487/04 ; C07D453/02 ; C07D401/12 ; A16K31/55
摘要：
Compounds of formula (I), ##STR1## wherein L is N or CR.sub.c, wherein R.sub.c is hydrogen, alkoxy, halo, alkyl or cyano; Q is NR.sub.1, CH.sub.2, O, or S; R.sub.a is hydrogen, halo, alkyl, amino, nitro or alkoxy; R.sub.b is hydrogen, halo, alkyl or alkoxy; R.sub.1 is hydrogen, alkyl, alkenyl, aralkyl, alkanoyl, or alkanoylalkyl; R.sub.2 is alkoxy; R.sub.3 is hydrogen, chloro or fluoro; R.sub.4 is hydrogen, alkyl, amino optionally substituted by alkyl, halo, hydroxy or alkoxy; R.sub.5 is hydrogen, halo, alkyl, alkoxy, nitro, amino or alkylthio; R.sub.6 is hydrogen, halo, alkyl, alkoxy or amino; n is 0, 1, 2, 3, or 4; p and m are independently 0, 1 or 2; and R.sub.q is hydrogen or C.sub.1-6 are 5-HT.sub.4 receptor antagonists.
公开/授权文献
- US4889163A Valve assembly 公开/授权日：1989-12-26
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