发明授权
- 专利标题： Heterocyclic derivatives
- 专利标题（中）： 杂环衍生物
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申请号： US218171申请日： 1994-03-28
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公开(公告)号： US5556977A公开(公告)日： 1996-09-17
- 发明人: Michael G. Wayne , Michael J. Smithers , John W. Rayner , Alan W. Faull , Robert J. Pearce , Andrew G. Brewster , Richard E. Shute , Sturat D. Mills , Peter W. R. Caulkett
- 申请人： Michael G. Wayne , Michael J. Smithers , John W. Rayner , Alan W. Faull , Robert J. Pearce , Andrew G. Brewster , Richard E. Shute , Sturat D. Mills , Peter W. R. Caulkett
- 申请人地址： GBX London
- 专利权人： Zeneca Limited
- 当前专利权人： Zeneca Limited
- 当前专利权人地址： GBX London
- 优先权： GBX9306453 19930329; GBX9325605 19931215
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; A61K31/4409 ; A61K31/4418 ; A61P7/02 ; C07D213/74 ; C07D401/00
摘要：
Compounds of formula I ##STR1## and metabolically labile esters and amides thereof, and pharmaceutically acceptable salts thereof, in which R.sup.13, M.sup.2, X.sup.1, Z.sup.1, Z.sup.1a, X.sup.2 and A.sup.1 have the meanings given in the specification. The compounds are useful as inhibitors of the binding of fibrinogen to glycoprotein IIb/IIIa. Intermediates are also disclosed.
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