发明授权
- 专利标题: Adhesion receptor antagonists III
- 专利标题(中): 粘附受体拮抗剂III
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申请号: US310085申请日: 1994-09-22
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公开(公告)号: US5561148A公开(公告)日: 1996-10-01
- 发明人: Joachim Gante , Horst Juraszyk , Peter Raddatz , Hanns Wurziger , Guido Melzer , Sabine Bernotat-Danielowski
- 申请人: Joachim Gante , Horst Juraszyk , Peter Raddatz , Hanns Wurziger , Guido Melzer , Sabine Bernotat-Danielowski
- 申请人地址: DEX Darmstadt
- 专利权人: Merck Patent Gesellschaft Mit Beshrankter Haftung
- 当前专利权人: Merck Patent Gesellschaft Mit Beshrankter Haftung
- 当前专利权人地址: DEX Darmstadt
- 优先权: DEX4332384.7 19930923
- 主分类号: A61K31/42
- IPC分类号: A61K31/42 ; A61K31/421 ; A61K31/44 ; A61K31/496 ; A61K31/505 ; A61P7/02 ; A61P9/08 ; A61P9/10 ; A61P19/10 ; A61P29/00 ; A61P33/04 ; A61P35/00 ; A61P43/00 ; C07D263/20 ; C07D263/24 ; C07D413/12 ; C07D263/38
摘要:
Novel oxazolidinone derivatives of the formula I ##STR1## in which R.sup.1 is a phenyl radical which is unsubstituted or is monosubstituted by CN, H.sub.2 N--CH.sub.2 --, A.sub.2 N--CH.sub.2 --, H.sub.2 N--C(.dbd.NH)--, H.sub.2 N--C(.dbd.NH)--NH--, H.sub.2 N--C(.dbd.NH)--NH--CH.sub.2 --, HO--NH--C(.dbd.NH)-- or HO--NH--C(.dbd.NH)--NH--,X is O, S, SO, SO.sub.2, --NH-- or --NA--,B is ##STR2## or ##STR3## A is alkyl having from 1 to 6 C atoms,R.sup.2 is H, A, Li, Na, K, NH.sub.4 or benzyl,R.sup.3 is H or (CH.sub.2).sub.n --COOR.sup.2,E is, in each case independently of each other, CH or N,Q is O, S or NH,m is 1, 2 or 3, andn is 0, 1, 2 or 3,and physiologically compatible salts thereof are provided, which inhibit the binding of fibrinogen to the corresponding receptor and can be used for treating thrombosis, stroke, cardiac infarction, inflammations, arteriosclerosis, osteoporosis and also tumors.
公开/授权文献
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