发明授权
- 专利标题: Method of lowering cholesterol
- 专利标题(中): 降低胆固醇的方法
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申请号: US468114申请日: 1995-06-06
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公开(公告)号: US5574071A公开(公告)日: 1996-11-12
- 发明人: Johannes Aebi , Philipe Guerry , Synese Jolidon , Olivier Morand
- 申请人: Johannes Aebi , Philipe Guerry , Synese Jolidon , Olivier Morand
- 申请人地址: NJ Nutley
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: NJ Nutley
- 优先权: CHX2107/93 19930714; CHX1320/94 19940428
- 主分类号: A61K31/24
- IPC分类号: A61K31/24 ; A61K31/135 ; A61K31/137 ; A61K31/138 ; A61K31/277 ; A61P3/06 ; A61P9/10 ; C07C211/26 ; C07C217/18 ; C07C217/20 ; C07C217/22 ; C07C217/46 ; C07C225/08 ; C07C225/14 ; C07C225/16 ; C07C225/22 ; C07C255/56
摘要:
A method of lowering cholesterol which comprises administering to a host requiring such treatment an effective amount of a compound of the formula ##STR1## wherein one of R.sup.1 and R.sup.2 is C.sub.1-7 -alkyl and the other is C.sub.1-7 -alkyl or C.sub.2-6 -alkenyl-methyl;L is C.sub.1-11 -alkylene or C.sub.2-11 -alkenylene optionally bonded to the phenyl group via an O atom or L is 1,4-phenylene;n is 0 or, when L contains an O atom, n is 0 or 1;Q is C.sub.1-7 -alkyl, C.sub.2-10 alkenyl or a group of formula ##STR2## wherein R is H, halogen, CF.sub.3, CN or NO.sub.2 ; R.sup.3 and R.sup.4 are H, C.sub.1-4 -alkyl or halogen; andR.sup.5 is H or, when R is H, R.sup.5 is H or halogen;or a pharmaceutically acceptable acid addition salt thereof, as well as certain compounds of formula I, are described.
公开/授权文献
- US4492282A Six-wheel armored vehicle 公开/授权日:1985-01-08
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