发明授权
US5576447A Process for the preparation of amidino phenyl pyrrolidine .beta.-alanine
urea analogs
失效
制备脒基苯基吡咯烷β-丙氨酸脲类似物的方法
- 专利标题： Process for the preparation of amidino phenyl pyrrolidine .beta.-alanine urea analogs
- 专利标题（中）： 制备脒基苯基吡咯烷β-丙氨酸脲类似物的方法
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申请号： US465212申请日： 1995-06-05
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公开(公告)号： US5576447A公开(公告)日： 1996-11-19
- 发明人: Norman A. Abood , Daniel L. Flynn , Scott A. Laneman , Roger Nosal , Lori A. Schretzman
- 申请人： Norman A. Abood , Daniel L. Flynn , Scott A. Laneman , Roger Nosal , Lori A. Schretzman
- 申请人地址： IL Chicago
- 专利权人： G. D. Searle & Co.
- 当前专利权人： G. D. Searle & Co.
- 当前专利权人地址： IL Chicago
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K31/4015 ; A61P7/02 ; C07C323/60 ; C07D207/26 ; C07D207/273
摘要：
The invention herein is directed to a process for producing a lactam of the formula ##STR1## from a methionine analog of the formula ##STR2## by treating the methionine analog with trimethylsulfonium halide or trimethylsulfoxonium halide in the presence of a base in a suitable aprotic solvent.The invention herein is further directed to the preparation of amidinophenyl pyrrolidinyl .beta.-alanine urea analogs using such methionine and lactam compounds as intermediates, which .beta.-alanine urea analogs are useful as antithrombotics.
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