An improved medication dispensing and control assembly is disclosed in which a carton has sidewalls defining a medication dispensing opening, which carton has at least one sidewall provided with a positioning slot for secure positioning in a tray. The carton has bendable top wall connected to the sidewalls to allow the top wall to move between a position closing the medication opening and opened positions allowing removal of medication from the cartons. A frame may be releasably attached to the top wall (for instance by teeth or other projections) so as to maintain planarity of the top wall to thereby facilitate carton opening and closing and maintaining the top wall portion in a closed condition and to resist any undesired bending thereof. The tray may be provided with anchoring tabs for slidable engagement with the positioning slot of the carton, thereby securing the carton in the tray while still allowing easy removal, and the carton may be provided with closing flaps to secure the carton in a closed position.