发明授权
US5605811A Methods and compositions for monitoring cellular processing of
beta-amyloid precursor protein
失效
用于监测β-淀粉样蛋白前体蛋白的细胞加工的方法和组合物
- 专利标题： Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein
- 专利标题（中）： 用于监测β-淀粉样蛋白前体蛋白的细胞加工的方法和组合物
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申请号： US440261申请日： 1995-05-12
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公开(公告)号： US5605811A公开(公告)日： 1997-02-25
- 发明人: Peter A. Seubert , Dale B. Schenk , Lawrence C. Fritz
- 申请人： Peter A. Seubert , Dale B. Schenk , Lawrence C. Fritz
- 申请人地址： South San Francisco IN Indianapolis
- 专利权人： Athena Neurosciences, Inc.,Eli Lilly and Company
- 当前专利权人： Athena Neurosciences, Inc.,Eli Lilly and Company
- 当前专利权人地址： South San Francisco IN Indianapolis
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; C07K16/18 ; G01N33/50 ; G01N33/68 ; C12Q1/02
摘要：
The present invention provides methods for identifying beta amyloid production inhibitors, wherein cells are cultured under conditions which result in secretion of a soluble fragment of beta amyloid precursor protein. The amino acid sequence of the fragment extends from the amino terminus of beta APP to the amino terminus of the beta amyloid peptide. The cultured cells are exposed to test compounds which cause a change in the secreted amount of the soluble fragment of beta APP which is determined.
公开/授权文献
- US4999824A Magneto-optical memory device 公开/授权日：1991-03-12
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