发明授权
- 专利标题： Compositions and methods for enhanced drug delivery
- 专利标题（中）： 用于增强药物递送的组合物和方法
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申请号： US449188申请日： 1995-05-24
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公开(公告)号： US5607691A公开(公告)日： 1997-03-04
- 发明人: Ron L. Hale , Amy Lu , Dennis Solas , Harold E. Selick , Kevin R. Oldenburg , Alejandro C. Zaffaroni
- 申请人： Ron L. Hale , Amy Lu , Dennis Solas , Harold E. Selick , Kevin R. Oldenburg , Alejandro C. Zaffaroni
- 申请人地址： GB2 Middlesex
- 专利权人： Affymax Technologies N.V.
- 当前专利权人： Affymax Technologies N.V.
- 当前专利权人地址： GB2 Middlesex
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; A61K9/127 ; A61K47/48 ; A61K9/70 ; A61K31/00
摘要：
The present invention relates to methods of delivering pharmaceutical agents across membranes, including the skin layer or mucosal membranes of a patient. A pharmaceutical agent is covalently bonded to a chemical modifier, via a physiologically cleavable bond, such that the membrane transport and delivery of the agent is enhanced.
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