发明授权
- 专利标题： Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
- 专利标题（中）： 噻吩羧酸和氨基醇的酯及其季铵化产物
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申请号： US405111申请日： 1995-03-16
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公开(公告)号： US5610163A公开(公告)日： 1997-03-11
- 发明人: Rolf Banholzer , Rudolf Bauer , Richard Reichl
- 申请人： Rolf Banholzer , Rudolf Bauer , Richard Reichl
- 申请人地址： DEX Ingelheim am Rhein
- 专利权人： Boehringer Ingelheim GmbH
- 当前专利权人： Boehringer Ingelheim GmbH
- 当前专利权人地址： DEX Ingelheim am Rhein
- 优先权： DEX3931041.8 19890916
- 主分类号： C07D451/10
- IPC分类号： C07D451/10 ; C07D451/14 ; A61K31/435 ; C07D401/00 ; C07D451/12
摘要：
Compounds of the formula ##STR1## of which, in exemplary compounds, the thienyl group is attached via the 2-position and:(a) A is 3.alpha.-(6.beta., 7.beta.-epoxy)-tropanyl methobromide and R.sub.1 is 2-thienyl;(b) A is 3.alpha.-(6, 7dehydro)-tropanyl methobromide and R.sub.1 is 2-thienyl;(c) A is 3.beta.-tropanyl methobromide and R.sub.1 is 2-thienyl; and,(d) A is 3.alpha.-(N-isopropyl)-nortropanyl methobromide and R.sub.1 is cyclopentyl.These are anticholinergics. Administered by inhalation, they are useful for the treatment of chronic obstructive bronchitis or slight to moderately severe asthma. Administered by the intravenous or oral routes, they are useful for the treatment of vagally induced sinus bradycardia.
公开/授权文献
- US4485377A LED Displays with high information content 公开/授权日：1984-11-27
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