发明授权
- 专利标题： Aprotinin analogs
- 专利标题（中）： 抑肽酶类似物
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申请号： US443977申请日： 1995-05-18
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公开(公告)号： US5621074A公开(公告)日： 1997-04-15
- 发明人: Soren E. Bj.o slashed.rn , Kjeld Norris , Viggo Diness , Leif N.o slashed.rskov-Lauritsen , Niels D. Christensen , Claus Bregengaard , Fanny Norris , Lars C. Petersen
- 申请人： Soren E. Bj.o slashed.rn , Kjeld Norris , Viggo Diness , Leif N.o slashed.rskov-Lauritsen , Niels D. Christensen , Claus Bregengaard , Fanny Norris , Lars C. Petersen
- 申请人地址： DKX Bagsvaerd
- 专利权人： Novo Nordisk A/S
- 当前专利权人： Novo Nordisk A/S
- 当前专利权人地址： DKX Bagsvaerd
- 优先权： DKX4501/87 19870828; DKX2254/88 19880426; DKX2361/90 19901001; DKX1118/91 19910612
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/81 ; A61K38/28 ; C07K1/00 ; C07K5/00
摘要：
The present invention relates to methods for producing aprotinin and analogs thereof in yeast, synthetic genes encoding such products, expression vectors and transformed yeast cells. The invention further relates to aprotinin analogs, particularly analogs with increased specific inhibitory activity and/or reduced nephrotoxicity compared to native aprotinin, as well as compositions comprising such analogs.
公开/授权文献
- US6135929A Walking assistance device 公开/授权日：2000-10-24