发明授权
- 专利标题： IGF-1 superagonists
- 专利标题（中）： IGF-1激素
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申请号： US435252申请日： 1995-05-05
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公开(公告)号： US5622932A公开(公告)日： 1997-04-22
- 发明人: Richard D. DiMarchi , Li Fan , Harlan B. Long
- 申请人： Richard D. DiMarchi , Li Fan , Harlan B. Long
- 申请人地址： IN Indianapolis
- 专利权人： Eli Lilly and Company
- 当前专利权人： Eli Lilly and Company
- 当前专利权人地址： IN Indianapolis
- 主分类号： A61K38/27
- IPC分类号： A61K38/27 ; A61K38/00 ; A61P43/00 ; C07K14/575 ; C07K14/65
摘要：
The instant invention provides two-chain IGF-1 superagonists which are derivatives of the naturally occurring single-chain IGF-1 having an abbreviated C domain. The invention also provides synthetic and semi-synthetic DNA sequences, recombinant DNA vectors and transformed host cells useful in the recombinant production of these analogs. The invention also provides pharmaceutical formulations comprising these IGF-1 analogs. The invention also provides methods of using these analogs in a variety of therapeutic applications. The instant invention provides IGF-1 analogs of the formula:BC.sup.n,A (1)wherein:B is the B domain of IGF-1 or a functional analog thereof,C is the C domain of IGF-1 or a functional analog thereof,n is the number of amino acids in the C domain and is from about 6 to about 12, andA is the A domain of IGF-1 or a functional analog thereof.
公开/授权文献
- US5015237A Pneumatic powered animal injector 公开/授权日：1991-05-14
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