发明授权
US5622983A N-substituted cycloalkyl and polycycloalkyl .alpha.-substituted Trp-Phe-
and phenethylamine derivatives
失效
N-取代的环烷基和多环烷基α-取代的Trp-Phe-和苯乙胺衍生物
- 专利标题： N-substituted cycloalkyl and polycycloalkyl .alpha.-substituted Trp-Phe- and phenethylamine derivatives
- 专利标题（中）： N-取代的环烷基和多环烷基α-取代的Trp-Phe-和苯乙胺衍生物
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申请号： US447141申请日： 1995-05-22
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公开(公告)号： US5622983A公开(公告)日： 1997-04-22
- 发明人: David C. Horwell , Martyn C. Pritchard , Edward Roberts , Reginald S. Richardson , Julian Aranda
- 申请人： David C. Horwell , Martyn C. Pritchard , Edward Roberts , Reginald S. Richardson , Julian Aranda
- 申请人地址： NJ Morris Plains
- 专利权人： Warner-Lambert Company
- 当前专利权人： Warner-Lambert Company
- 当前专利权人地址： NJ Morris Plains
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07D209/20 ; C07D401/12 ; C07D403/12 ; C07D405/12 ; C07D409/12 ; C07F7/08 ; C07K5/078 ; C07K5/097 ; A61K31/405 ; A61K31/41
摘要：
Novel unnatural dipeptoids of .alpha.-substituted Trp-Phe derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, colorectal tumors, or as antipsychotics are disclosed. Further the compounds are antianxiety agents, antiulcer agents, antidepressant agents, and are agents useful for preventing the withdrawal response produced by chronic treatment or use followed by chronic treatment followed by withdrawal from nicotine, diazepam, alcohol, cocaine, caffeine, or opiods. Also disclosed are pharmaceutical compositions and methods of treatment using the dipeptoids as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds to prepare pharmaceutical and diagnostic compositions.
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