发明授权
- 专利标题: Methods of treating Giardia lamblia
- 专利标题(中): 治疗贾第鞭毛虫的方法
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申请号: US454838申请日: 1995-05-31
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公开(公告)号: US5627184A公开(公告)日: 1997-05-06
- 发明人: David W. Boykin , Christine C. Dykstra , Richard R. Tidwell , James E. Hall , W. David Wilson , Arvind Kumar
- 申请人: David W. Boykin , Christine C. Dykstra , Richard R. Tidwell , James E. Hall , W. David Wilson , Arvind Kumar
- 申请人地址: NC Chapel Hill GA Atlanta
- 专利权人: The University of North Carolina at Chapel Hill,Georgia State University Research Foundation, Inc.
- 当前专利权人: The University of North Carolina at Chapel Hill,Georgia State University Research Foundation, Inc.
- 当前专利权人地址: NC Chapel Hill GA Atlanta
- 主分类号: G01N33/50
- IPC分类号: G01N33/50 ; A61K31/505 ; A61K31/506 ; C07D239/26 ; C07D307/52 ; C07D307/54 ; C07D307/58 ; C07D403/10 ; C07D403/14 ; C07D405/14 ; C09B23/01 ; C12Q1/68 ; G01N21/78 ; G01N33/52 ; G01N33/58
摘要:
The present invention provides methods for treating Pneumocystis carinii pneumonia and Giardia lamblia in a subject in need of such treatment. The methods comprises administering to the subject a compound of Formula I: ##STR1## wherein: X and Y are located in the para or meta positions and are selected from the group consisting of H, loweralkyl, loweralkoxy, and ##STR2## wherein: each R.sub.1 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R.sub.1 groups together represent C.sub.2 -C.sub.10 alkyl, hydroxyalkyl, or alkylene, or two R.sub.1 groups together represent ##STR3## wherein m is from 1-3 and R.sub.7 is H or --CONHCR.sub.8 NR.sub.9 R.sub.10, wherein R.sub.8 is loweralkyl, and R.sub.9 and R.sub.10 are each independently selected from the group consisting of H and lower alkyl;R.sub.2 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl;n is a number from 0 to 2;R.sub.3 and R.sub.4 are each independently selected from the group consisting of H, loweralkyl, loweralkoxy, alkylaryl, aryl, oxyaryl, aminoalkyl, aminoaryl, or halogen; andR.sub.5 and R.sub.6 are each independently selected from the group consisting of H, loweralkyl, aryl, alkylaryl, aminoalkyl, aminoaryl, halogen, oxyalkyl, oxyaryl, or oxyarylalkyl; or a phamaceutically acceptable salt thereof. The compound of Formula I is administered in an amount effective to treat the condition.The present invention also provides compounds useful for the treatment of Pneumocystis carinii pneumonia and Giardia lamblia.
公开/授权文献
- USD322681S Combined fluorescent lantern and clip 公开/授权日:1991-12-24
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