发明授权
- 专利标题: Method to stabilize a pharmaceutical composition and its production
- 专利标题(中): 稳定药物组合物及其制备方法
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申请号: US488152申请日: 1995-06-07
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公开(公告)号: US5639478A公开(公告)日: 1997-06-17
- 发明人: Tadashi Makino , Tetsuro Tabata , Shin-Ichiro Hirai
- 申请人: Tadashi Makino , Tetsuro Tabata , Shin-Ichiro Hirai
- 申请人地址: JPX Osaka
- 专利权人: Takeda Chemical Industries, Ltd.
- 当前专利权人: Takeda Chemical Industries, Ltd.
- 当前专利权人地址: JPX Osaka
- 优先权: JPX61-29567 19860213; JPX61-38059 19860221
- 主分类号: A61K9/16
- IPC分类号: A61K9/16 ; A61K9/20 ; A61K9/30 ; A61K9/50 ; A61K31/44 ; A61K31/4439 ; A61K47/02 ; C07D401/12
摘要:
The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula ##STR1## wherein R.sup.1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R.sup.2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R.sup.3 and R.sup.5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R.sup.4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt stabilizing agent, is physically stable. Magnesium and calcium basic inorganic salt stabilizing agents are particularly useful.
公开/授权文献
- US5050640A Water supply installation 公开/授权日:1991-09-24
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