Invention Grant
US5639745A Fused-bicyclic lactams as interleukin-1.beta. converting enzyme
inhibitors
失效
融合双环内酰胺作为白细胞介素-1β转换酶抑制剂
- Patent Title: Fused-bicyclic lactams as interleukin-1.beta. converting enzyme inhibitors
- Patent Title (中): 融合双环内酰胺作为白细胞介素-1β转换酶抑制剂
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Application No.: US451108Application Date: 1995-05-25
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Publication No.: US5639745APublication Date: 1997-06-17
- Inventor: Roland E. Dolle , Prasad V. Chaturvedula , Tina Morgan Ross , Stanley J. Schmidt
- Applicant: Roland E. Dolle , Prasad V. Chaturvedula , Tina Morgan Ross , Stanley J. Schmidt
- Applicant Address: FRX Paris Cedex
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FRX Paris Cedex
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/535 ; A61K31/55 ; A61K38/00 ; A61P29/00 ; A61P35/00 ; A61P37/06 ; A61P43/00 ; C07D471/04 ; C07D513/04 ; C07K5/02 ; C07K5/06 ; C07K5/078
Abstract:
Disclosed are compounds, compositions and methods for inhibiting interleukin-1.beta. protease activity. The compounds, bicyclic derivatives of aldehydes and .alpha.-substituted methyl ketones, have the formula (A) set out herein.
Public/Granted literature
- US4999582A Biosensor electrode excitation circuit Public/Granted day:1991-03-12
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