发明授权
- 专利标题： Synthetic oligonucleotides which mimic telomeric sequences for use in treatment of cancer and other diseases
- 专利标题（中）： 模仿用于治疗癌症和其他疾病的端粒序列的合成寡核苷酸
-
申请号： US381097申请日： 1995-01-31
-
公开(公告)号： US5643890A公开(公告)日： 1997-07-01
- 发明人: Patrick L. Iversen , John E. Mata
- 申请人： Patrick L. Iversen , John E. Mata
- 申请人地址： NE Lincoln
- 专利权人： The Board of Regents of the University of Nebraska
- 当前专利权人： The Board of Regents of the University of Nebraska
- 当前专利权人地址： NE Lincoln
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C12N15/113 ; A61K48/00 ; C07H21/04 ; C12N5/10
摘要：
A method of inhibiting proliferation of immortal cells or cells that express telomerase is disclosed. The method includes introduction of synthetic oligonucleotides which mimic telomere motifs. Quite surprisingly applicant has demonstrated that a single telomere motif, TTAGGG exhibits greater cellular uptake and higher inhibition of proliferation than longer oligonucleotides, which were previously thought to be necessary to achieve sequence specific interaction with telomerase.
公开/授权文献
信息查询
IPC分类:
