发明授权
- 专利标题: Controlled release of active agents using inorganic tubules
- 专利标题(中): 使用无机小管控制活性剂的释放
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申请号: US509483申请日: 1995-07-31
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公开(公告)号: US5651976A公开(公告)日: 1997-07-29
- 发明人: Ronald R. Price , Bruce P. Gaber
- 申请人: Ronald R. Price , Bruce P. Gaber
- 申请人地址: DC Washington
- 专利权人: The United States of America as represented by the Secretary of the Navy
- 当前专利权人: The United States of America as represented by the Secretary of the Navy
- 当前专利权人地址: DC Washington
- 主分类号: A01N25/08
- IPC分类号: A01N25/08 ; A61K9/00 ; A01N25/28
摘要:
The present invention is a composition for, and a method of, delivering an active agent at a controlled rate. The composition of the invention is a hollow ceramic or inorganic microtubule, where the active agent is contained within the lumen of the microtubules. Typically, the agent is adsorbed onto an inner surface of the microtubule. The method of the invention is disposing this novel composition in a use environment. In a preferred embodiment of the invention, a microtubule is a tubule having an inner diameter of less than 0.2 .mu.m, and microtubules are tubules having an average inner diameter less than 0.2 .mu.m. In a preferred embodiment, the hollow ceramic or inorganic microtubule is a mineral microtubule, such as halloysite, cylindrite, boulangerite, or imogolite. In a more preferred embodiment of the invention, the mineral microtubule has a biodegradable polymeric carrier disposed in its lumen. In a preferred embodiment of the invention, the inner diameter of the microtubules varies from about 0.20 .mu.m to about 0.35 .mu.m, or averages about 0.40 .mu.m. In another preferred embodiment, of the invention, the inner diameter of the microtubules varies from about 200 .ANG. to about 1000 .ANG..
公开/授权文献
- US5315204A Piezoelectric snap action switch 公开/授权日:1994-05-24
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