发明授权
US5652234A 3-(7-oxo-1-aza-4-oxabicyclo[3.2.0]hept-3-yl)alanine derivative as
antitumor agent
失效
3-（7-氧代-1-氮杂-4-氧杂双环[3.2.0]庚-3-基）丙氨酸衍生物作为抗肿瘤剂
- 专利标题： 3-(7-oxo-1-aza-4-oxabicyclo[3.2.0]hept-3-yl)alanine derivative as antitumor agent
- 专利标题（中）： 3-（7-氧代-1-氮杂-4-氧杂双环[3.2.0]庚-3-基）丙氨酸衍生物作为抗肿瘤剂
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申请号： US513803申请日： 1995-10-06
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公开(公告)号： US5652234A公开(公告)日： 1997-07-29
- 发明人: Rajeshwar Singh , Tomohiro Yamashita , Charles Fiakpui , George Thomas , Chan Ha , Hiroshi Matsumoto , Toshio Otani , Shinji Oie , Ronald Micetich
- 申请人： Rajeshwar Singh , Tomohiro Yamashita , Charles Fiakpui , George Thomas , Chan Ha , Hiroshi Matsumoto , Toshio Otani , Shinji Oie , Ronald Micetich
- 申请人地址： JPX Tokyo CAX Edmonton
- 专利权人： Taiho Pharmaceutical Co., Limited,SynPhar Laboratories, Inc.
- 当前专利权人： Taiho Pharmaceutical Co., Limited,SynPhar Laboratories, Inc.
- 当前专利权人地址： JPX Tokyo CAX Edmonton
- 优先权： GBX9400239 19940107
- 主分类号： C07D503/00
- IPC分类号： C07D503/00 ; A61K31/42 ; A61P35/02 ; A61K31/395
摘要：
The present invention relates to the use of 3-(7-oxo-1-aza-4-oxabicyclo[3.2.0]hept-3-yl)alanine derivatives of formula (I) or a pharmaceutically acceptable salt thereof, as antitumor agents. ##STR1## Wherein R is: hydrogen or COOR.sub.2 wherein R.sub.2 is C.sub.1 -C.sub.3 alkyl group which may be substituted with aryl group.Wherein R.sub.1 is:hydrogen or C.sub.1 -C.sub.3 alkyl group which may be substituted with one or two aryl groups.
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