发明授权
US5652366A DI (1R)-(-)camphosulfonic acid) salt, preparation thereof and use thereof
失效
DI（1R） - （ - ）樟脑磺酸）盐，其制备及其用途
- 专利标题： DI (1R)-(-)camphosulfonic acid) salt, preparation thereof and use thereof
- 专利标题（中）： DI（1R） - （ - ）樟脑磺酸）盐，其制备及其用途
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申请号： US484811申请日： 1995-06-07
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公开(公告)号： US5652366A公开(公告)日： 1997-07-29
- 发明人: Alfred P. Spada , Cynthia A. Fink , Michael R. Myers , Laurence W. Reilly , Benoit J. Vanasse
- 申请人： Alfred P. Spada , Cynthia A. Fink , Michael R. Myers , Laurence W. Reilly , Benoit J. Vanasse
- 申请人地址： PA Collegeville
- 专利权人： Rhone-Poulenc Rorer Pharmaceuticals Inc.
- 当前专利权人： Rhone-Poulenc Rorer Pharmaceuticals Inc.
- 当前专利权人地址： PA Collegeville
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D473/00 ; C07H19/052 ; C07H19/16
摘要：
This invention relates to di[(1 R)-(-)-camphosulfonic acid) salt of [1S-[1.alpha.,2.beta.,3.beta.,4.alpha.,(S*)]]-4-[7-[[2-(3-chloro-2-thienyl)-1-ethylethyl]amino]3 H-imidazo[4,5-b]pyridin-3-yl]-N-ethyl-2,3-dihydroxycyclopentanecarboxamide, and a process for preparing the compound, comprising reacting a reaction mixture of (-)-1.beta.-N-ethyl-2.alpha.,3.alpha.-isopropylidenedioxy-4.beta.-[3-amino-4-[2-(5-chloro-2-thienyl)-(1R)-1-ethylethyl]amino-2-pyridyl]aminocyclopentanecarboxamide and formamidine acetate, and then treating the reaction mixture with (1 R)-(-)-10-camphorsulfonic acid.The salt is useful in purifying [1 S-[1.alpha.,2.beta.,3.beta.,4.alpha.,(S*)]]-4-[7-[[2-(3-chloro-2-thienyl)-1-ethylethyl]amino]-3 H-imidazo[4,5-b]pyridin-3-yl]-N-ethyl-2,3-dihydroxycyclopentanecarboxamide which possesses adenosine agonist activity and is useful as an anti-hypertensive, cardioprotective, anti-ischemic, and antilipolytic agent.
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