An internal combustion engine misfire sensing circuit comprises an ion current sensing circuit for sensing an ion current in the combustion chamber of an internal combustion engine, a current/voltage conversion circuit for converting the sensed ion current into a voltage and a waveform shaping circuit for shaping the waveform of an output of the current/voltage conversion circuit. The waveform shaping circuit includes a second comparator for comparing a voltage of a third capacitor with first and second reference voltages for outputting a misfire sensing signal and a capacitor charging/discharging circuit for charging the third capacitor in response to the rising up of an output of the current/voltage conversion circuit and discharging the third capacitor based on the input of the misfire sensing signal. With this arrangement a misfire can be sensed even in an internal combustion engine having multiple cylinders, the number of parts can be reduced as well as the area of circuits can be reduced.