发明授权
US5656643A Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF
and/or PDGF receptor tyrosine kinase
失效
抑制EGF和/或PDGF受体酪氨酸激酶的双单和双环芳基和杂芳基化合物
- 专利标题: Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
- 专利标题(中): 抑制EGF和/或PDGF受体酪氨酸激酶的双单和双环芳基和杂芳基化合物
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申请号: US385258申请日: 1995-02-08
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公开(公告)号: US5656643A公开(公告)日: 1997-08-12
- 发明人: Alfred P. Spada , Martin P. Maguire , Paul E. Persons , Michael R. Myers
- 申请人: Alfred P. Spada , Martin P. Maguire , Paul E. Persons , Michael R. Myers
- 申请人地址: PA Collegeville
- 专利权人: Rhone-Poulenc Rorer Pharmaceuticals Inc.
- 当前专利权人: Rhone-Poulenc Rorer Pharmaceuticals Inc.
- 当前专利权人地址: PA Collegeville
- 主分类号: A61K31/4375
- IPC分类号: A61K31/4375 ; A61K31/47 ; A61K31/4709 ; A61K31/4725 ; A61K31/498 ; A61K31/517 ; C07D213/64 ; C07D215/20 ; C07D401/04 ; C07D409/04 ; C07D401/06 ; C07D401/12
摘要:
This invention relates to bis mono- and/or bicyclic aryl and/or heteroaryl compounds exhibiting protein tyrosine kinase inhibition activity. More specifically, it relates to the method of inhibiting abnormal cell proliferation in a patient suffering from a disorder characterized by such proliferation comprising the administration thereto of an EGF and/or PDGF receptor inhibiting effective amount of said bis mono- and/or bicyclic aryl and/or heteroaryl compound and to the preparation of said compounds and their use in pharmaceutical compositions used in this method.
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