Invention Grant
- Patent Title: Phenylalanine derivatives as endothelin antagonists
- Patent Title (中): 苯丙氨酸衍生物作为内皮素拮抗剂
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Application No.: US369209Application Date: 1995-01-05
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Publication No.: US5658943APublication Date: 1997-08-19
- Inventor: Kent Alan Berryman , Xue-Min Cheng , Annette Marian Doherty , Jeremy John Edmunds , Sylvester Klutchko
- Applicant: Kent Alan Berryman , Xue-Min Cheng , Annette Marian Doherty , Jeremy John Edmunds , Sylvester Klutchko
- Applicant Address: NJ Morris Plains
- Assignee: Warner-Lambert Company
- Current Assignee: Warner-Lambert Company
- Current Assignee Address: NJ Morris Plains
- Main IPC: C07C229/36
- IPC: C07C229/36 ; C07C233/51 ; C07C275/28 ; C07C323/59 ; C07D317/54 ; C07D317/60 ; C07C229/30 ; C07C317/60
Abstract:
Novel antagonists of endothelin are described, as well as novel intermediates used in their preparation, methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, essential, renovascular, malignant and pulmonary hypertension, cerebral infarction, myocardial ischemia, cerebral ischemia, congestire heart failure and subarachnoid hemorrhage.
Public/Granted literature
- US4924049A Bacon Box Public/Granted day:1990-05-08
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